1 September 2020

4D pharma hosts R&D webinar providing an overview of world leading Live Biotherapeutic discovery platform, MicroRx®

Presentation is followed by Q&A session with analysts


Leeds, UK, 4D pharma plc (AIM: DDDD), a pharmaceutical company leading the development of Live Biotherapeutics, today presents their R&D webinar discussing the science behind their Live Biotherapeutic drug discovery engine, MicroRx®.

The event is introduced by Dr. Alex Stevenson, Chief Scientific Officer, 4D pharma, and presented by Dr Imke Mulder, Research Director, 4D pharma, alongside three senior members of her Research team. The presentation provides detailed insights in to 4D’s MicroRx platform, followed by covering analysts participating in a question and answer session.

Topics include:

  • Why 4D’s focus on the mechanism of single-strain LBPs drives a rational drug discovery approach and guides effective development
  • How the MicroRx platform investigates functionality
  • The drug discovery process and considerations for the microbiome
  • 4D’s proprietary culture collection
  • Neurodegenerative diseases and 4D pharma candidates - MRx0029 and MRx0005
  • MRx0518, oncology and the MicroRx platform

A recording of the event, the presentation slides and a transcript are accessible via the “Reports and Presentations” area of 4D’s website at www.4dpharmaplc.com/en/investors/reports-presentations.

The microbiome is a novel area of medicine with profound impacts on human health and disease.4D pharma recently announced proof of concept data for their lead immuno-oncology candidate MRx0518 in combination with Keytruda, highlighting that the 42% disease control rate observed in Part A of the study, far exceeded the predefined 10% threshold for expansion. This, in addition with 4D pharma holding the largest IP portfolio and working in diverse therapy areas, has driven increased interest in the Company’s science and development from a range of stakeholders.

Dr Imke Mulder has led the multidisciplinary research group at 4D pharma since 2014, developing the MicroRx® platform and discovering new Live Biotherapeutics. After completing her BSc and MSc in Biology at Wageningen University in the Netherlands, she moved to Aberdeen for her PhD, studying on the effects of dietary components on the gut immune system. Imke then carried out 8 years of post-doctoral work as a Research Fellow in the Gut Immunology Group at the Rowett Institute of Nutrition and Health (RINH) in Aberdeen. This work primarily focused on interactions between the gut microbiota and the host immune system in different model organisms.

An insightful Q&A session follows the presentation involving analysts from Chardan, N+1 Singer, Bryan, Garnier & Co., Cantor Fitzgerald, Jefferies, Jones Trading and Ladenburg Thalmann & Co.




About 4D

Founded in February 2014, 4D pharma is a world leader in the development of Live Biotherapeutics, a novel and emerging class of drugs, defined by the FDA as biological products that contain a live organism, such as a bacterium, that is applicable to the prevention, treatment or cure of a disease.  4D has developed a proprietary platform, MicroRx(R), that rationally identifies Live Biotherapeutics based on a deep understanding of function and mechanism.

4D's Live Biotherapeutic Products are orally delivered single strains of bacteria that are naturally found in the healthy human gut. The Company has six clinical studies in progress, namely a Phase II clinical study of BLAUTIX(R) in Irritable Bowel Syndrome (IBS), a Phase I/II study of MRx0518 in combination with KEYTRUDA (pembrolizumab) in solid tumours, a Phase I study of MRx0518 in a neoadjuvant setting for patients with solid tumours, a Phase I study of MRx0518 in patients with pancreatic cancer, a Phase I/II study of MRx-4DP0004 in asthma, and a Phase II study of MRx-4DP0004 in patients hospitalised with COVID-19. Preclinical-stage programs include candidates for CNS disease such as Parkinson's disease and other neurodegenerative conditions. The Company has a research collaboration with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ, USA, to discover and develop Live Biotherapeutics for vaccines.

For more information, refer to https://www.4dpharmaplc.com.


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