Join us

At 4D pharma, we understand that developing a new therapeutic class is challenging. We also understand that our people are our greatest resource – and we look to recruit ambitious and talented individuals from all over the world to be part of this exciting new area of medicine.

Please see our current career opportunities below:

Purpose of the Job

The successful candidate will primarily provide scientific expertise to the activities of the Discovery II Host team at 4D Pharma Research Ltd in Aberdeen. The primary focus of the team is to investigate the mechanisms behind the host-microbe interactions of our preclinical LBP candidates. Proficiency in running a variety of cellular and molecular techniques is required along with independent and flexible working. The post-holder will also be responsible for writing reports and SOPs, contributing to writing papers, present at internal and external meetings.

Experience / Qualifications Required

  • PhD Degree or Higher National Certificate in molecular biology, biomedical sciences, or other science-related discipline or at least 5 years experience working in an industrial environment in a similar role
  • Proven expertise in immunology
  • Competency in designing and developing cell-based assays to investigate the MoA of LBP candidates
  • Competency with isolation and culture of primary cells from tissue samples (e.g. gut, spleen, lymph nodes) or human samples (e.g. blood)
  • Proven expertise in single-cell analysis techniques (e.g. multiparameter flow cytometry)
  • Data analysis and interpretation
  • Keep accurate and detailed records of produced results
  • Good organisational and communication skills
  • Ability to work both within a team and independently
  • Experience with basic microbiology techniques is desirable

Key Areas of Responsibility

  • Run assay development and validation for the characterisation of LBPs
  • Analyse data and report results to the Team Leader and senior members of the team
  • Perform laboratory techniques and protocols according to SOPs
  • Provide scientific support to the Discovery II (Host) team
  • Keep accurate and detailed records of data
  • Attend and contribute to research group meetings
  • Train junior members of the team
  • Represent the company at international conferences

How to Apply

Please send all applications including a CV and covering letter to hr@4dpharmaplc.com.

Purpose of the Job

The successful candidate will perform testing required to support the core research and development program of the Discovery I Micro team at 4D Pharma Research in Aberdeen. The primary focus of the Discovery 1 Micro team is to carry out high-throughput and secondary screening of 4D Pharma’s strain library to identify candidate LBPs capable of modulating host-microbe interactions. The Research Scientist is required to make scientific observations, maintain detailed workbooks/ documentation and ensure all documentation fulfils generally accepted professional/industry standards. The Research scientist will be expected to propose new screening strategies and introduce and validate new screening approaches/methods ensuring they are current and compliant with industry standards and regulations. Requirements also include maintaining a thorough understanding of 4D Pharma’s services, technical principles and applications. Proficiency in running a variety of assays and molecular techniques are required along with independent and flexible working. The post holder will also be responsible for writing reports and SOPs, contributing to writing papers and present findings at internal and external meetings.

Essential Qualifications

  • PhD Degree in Microbiology, Biomedical sciences or other closely-related discipline or at least 5 years of experience working in an industrial environment in a similar role.

Essential experience

  • Competency with microbiology techniques especially in the cultivation of anaerobic microbes.
  • Competency with cell culture techniques.
  • Competency in a range of screening assays relevant to host-microbe interactions.
  • Expertise in HPLC- extraction, detection and quantification of small molecules/secondary metabolites of interest in cell-free supernatants or extracts.

Desirable experience

  • Experience in assays using co-culture systems (bacteria & host cells)
  • Competency in a variety of molecular laboratory techniques, including nucleic acid extraction, PCR and qPCR and imaging techniques such as CLSM and SEM.
  • Expertise in running anaerobic bioreactors and in the techniques used to monitor microbial community composition.
  • Experience with biofilm-related techniques- total biomass, viability and susceptibility testing.
  • Experience in immunological assays.
  • Bioinformatics- genome mining and NGS.

Personal skills

  • Contribute ideas and suggestions to improve standard laboratory techniques, improve protocols, processes and equipment.
  • Introduce and validate new screening approaches/methods that are current and compliant with industry standards and regulations.
  • Create/revise SOPs, laboratory records and other related documentation as assigned.
  • Good organisational and communication skills.
  • Good problem solving skills- ability to “think out of the box”.
  • Team worker.

Key Areas of Responsibility

  • Running assay development and validation for the discovery and characterisation of LBPs, in particular where gut cells and bacteria are involved.
  • Introduce and validate new screening approaches/methods ensuring they are current and compliant with industry standards and regulations.
  • Report results to the Team Leader and senior members of the team.
  • Perform laboratory techniques and protocols according to SOPs and provide technical support to the Discovery I Micro team.
  • Interact and liase with the Discovery I Host team.
  • Keep accurate and detailed records of data.
  • Attend and contribute to research group meetings and external event.

How to Apply

Please send all applications including a CV and covering letter to hr@4dpharmaplc.com.


Purpose of the Job

We are looking for a CSM to be predominately office based in our headquarters in Leeds. This individual will report to the Director of Clinical Operations and Alliance Management and will ultimately have line management responsibility for a small growing team of Clinical Trial Associates and Junior CRAs as the company continues to expand. A large part of the role is managing CROs who have the responsibility of taking 4D Pharma’s pipeline into the Clinic on an international basis. This will include co-monitoring and being the primary point of contact for the CRO core team. This position would suit an individual with both CRO and Pharmaceutical experience who is ready for the next chapter in their career, involving less direct on-site monitoring and more internal study management.

Key Areas of Responsibility

  • Internal study management (document review and approval/ budget and timeline review/resolve issues on an on-going basis and pro-actively review risk and develop risk mitigation plans) of growing number of studies outsourced to CROs
  • Development of a monitoring program, based on a risk-based approach for all active studies to ensure Sponsor oversight compliance
  • Develop Monitoring SOPs as required
  • Attend site visits with CRO personnel to review processes and develop relationships with investigators
  • Form strong and productive relationships with peers and works collaboratively with key cross functional teams within 4D Pharma structure
  • Champions effective coaching and development of more junior members of the team and helps to support the Clinical Operations Director in retention of high value performers
  • Involvement with on-going CRO selection
  • Helps and support the Clinical Operations Director in the development of Clinical department working practices and processes as required

Essential Experience

  • Recent role within a CRO/ Pharmaceutical or Biotech Company
  • Direct and recent (within the last two years) on-site monitoring experience
  • Detailed knowledge of ICH/GCP, recent updates and adaptive monitoring approaches
  • Previous involvement with Investigator Meetings and Site training
  • Significant understanding of core teams within the Clinical Trial setting; Regulatory, Safety, Medical writing, Data Management, statistics and IMP management
  • Ability to work effectively and independently to fast-moving timelines within a fast-paced working environment
  • A flexible and collaborative nature
  • Operationally strong and delivery focused
  • Ability to travel as required within the UK and outside (current full driving licence and valid passport)
  • Fluent in written and spoken English

Desirable Experience

  • Line management
  • CRA Team training
  • Lead CRA experience on a global study
  • Oncology/Respiratory and Gastroenterology Therapy experience
  • Global Awareness and cultural sensitivity
  • Experience with Electronic Clinical Outcome Assessment (eCOA)

Qualifications Required

  • Degree in a health or scientific discipline or relevant industry experience of 10 years or more
  • At least 7 years Clinical Research experience, 5 years of which is specific CRA experience (including feasibility assessments/ site set-up and management/ direct site monitoring and eCRF processes)

Purpose of the Job


Responsible for working in collaboration with the Clinical Development team to successfully and proactively manage study-specific electronic Trial Master Files (eTMF). Responsibilities include creating and maintaining TMF governance documentation, performing quality reviews of TMFs for completeness, performing record review for accuracy and quality to achieve TMFs that are in an ongoing state of inspection readiness. Provides support to clinical development in project delivery.


Key Areas of Responsibility


  • Set up, implementation and maintenance of an eTMF
  • Act as superuser and primary contact for queries relating to eTMF
  • Maintenance of documents filed in the paper TMFs
  • Supports Quality Control of the TMF on a regular basis
  • Perform an ongoing quality control of the eTMF, with the relevant functions (sponsor / vendor) until their resolution. Ensure its inspection readiness i.e. completeness and compliance with the relevant requirements from study start-up until archiving
  • Escalate to the relevant functions any limiting factors and non-compliance related to the eTMF quality and provide comprehensive guidance on issue resolution
  • Act as TMF subject matter expert (SME)/ point of contact for study teams and TMF stakeholders
  • Contribute to the revisions of the eTMF process and system enhancements
  • Produce and manage site/ study/ business level TMF reports and metrics provide to study teams who us the eTMF as the repository of their TMF records
  • Archiving of paper and eTMFs
  • Provide support by eTMF related audit or inspections
  • Arrange secure shipments of wet-ink documents
  • Work with multi-functional study teams and vendors to ensure the maintenance of TMFs, both electronic and paper, in a state of inspection readiness
  • Assist in preparation of study documents; ICF, protocols etc
  • Development and management of tracking tools for protocol related costs
  • Sourcing and oversight of ancillary supplies
  • Other activities as required


Essential Experience


  • Minimum clinical research 3 years’ experience
  • Ideally degree life sciences degree or equivalent
  • Knowledge of clinical development phases and processes including GCP and ICH regulations
  • Experience of working with eTMF systems and related standards e.g. reference model
  • Previous experience overseeing TMF audits, internal and/or regulatory audits preferred
  • Experience in overseeing and training employees and vendors on eTMF processes
  • Proficiency in Microsoft Office (Word, Excel, Outlook)
  • Superior written and spoken communication skills in English

Desirable Experience/Attributes


  • Able to multitask in a fast-paced environment
  • Ability to work well with people from a variety of different backgrounds and cultures
  • Ability to build relationships with clients and co-workers
  • Can work independently and as part of a team
  • Takes active measures to solve problems and commit to a high level of service.

To apply, please send all applications to hr@4dpharmaplc.com including your CV and covering letter.


We always welcome applications from talented individuals even if a role is not advertised we would be keen to hear from you. Please send your CV to hr@4dpharmaplc.com

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