Join us

At 4D pharma, we understand that developing a new therapeutic class is challenging. We also understand that our people are our greatest resource – and we look to recruit ambitious and talented individuals from all over the world to be part of this exciting new area of medicine.

Please see our current career opportunities below:


About the Company

4D pharma plc is a pharmaceutical company focussed on developing therapeutics from the human gut microbiome. Live biotherapeutic products (LBPs) derived from the gut microbiome represent a new class of drug that contain live organisms for the prevention, treatment or cure of disease. 4D pharma is a world leader in the LBP field and currently has a number of clinical stage programmes in oncology, asthma, IBS and IBD, and a strong pipeline of additional pre-clinical programmes in CNS disease, oncology autoimmunity and inflammation.


Purpose of the Job

Applications are invited for the role of Research Scientist – Immunology – to join the research team at 4D Pharma Research Ltd in Aberdeen (UK). The successful candidate will provide scientific expertise in drug discovery for the proprietary MicroRx platform, identifying candidate LPBs for different therapeutic areas. This is mainly focussed on defining suitable properties of LBPs in novel disease areas using appropriate in vitro and ex vivo readouts by integrating cellular, molecular, and immune endpoints to study the modulation of the host immune system and support translational development of LBPs. The candidate will also be involved in pre-clinical efficacy studies and investigate the mechanisms behind LBP-host interactions. The role will require proven hands-on expertise in a range of immunological techniques, including human and murine cellular assays, immune cell isolation and differentiation (lymphoid and myeloid populations), ELISA-based assays, proficiency in multi-parameter flow cytometry, and a proven ability to translate these skills into robust and reliable data. The post-holder will have the opportunity to engage in the wider research activities of the 4D Pharma Research team, write up results in the form of reports and publications, present research outcomes at meetings, and generate intellectual property.


Experience / Qualifications Required

  • PhD in Immunology, or other relevant discipline, ideally with 3 years’ experience working in an industry environment in similar role
  • Proven expertise in innate immunology and/or microbe-host interactions
  • Strong experience in isolation, culturing and immunophenotyping of primary cells from blood or tissues
  • Experience in a variety of laboratory techniques such as multi-parameter flow cytometry (15+ colours), primary and immortalised cell culture, ELISA-based assays (multiplex), nucleic acid extraction (DNA and RNA), qPCR, immunofluorescence staining
  • Experience working in vivo essential; familiarity with animal models relevant to 4D pipeline (e.g., immuno-oncology, CNS, gastro-intestinal, asthma, autoimmune diseases). Personal licence ownership or willingness to acquire licence
  • Excellent analytical, problem-solving, and organisational skills with attention to detail
  • Strong communication and interpersonal skills and experience in supervising junior members of staff


Key Areas of Responsibility

  • Assay development and validation for the characterisation of LBPs
  • Analyse data and report results to the Team Leader and other senior members of staff
  • Perform laboratory techniques and protocols according to SOPs
  • Provide scientific support to the Discovery (Host) team
  • Keep accurate and detailed records of data
  • Attend and contribute to research group meetings
  • Train junior members of the team


How to apply

Please send all applications to:

Lucy Christie

hr@4dpharmaplc.com

Telephone 01224 900 460

About the Company

4D pharma plc is a pharmaceutical company focussed on developing therapeutics from the human gut microbiome. Live biotherapeutic products (LBPs) derived from the gut microbiome represent a new class of drug that contain live organisms for the prevention, treatment or cure of disease. 4D pharma is a world leader in the LBP field and currently has a number of clinical stage programs in oncology, asthma, IBS and IBD, and a strong pipeline of additional pre-clinical programs in CNS disease, oncology, autoimmunity and inflammation.


Purpose of the Job

Applications are invited for the role of Research Scientist in Neuroscience to join the research team at 4D Pharma Research Ltd in Aberdeen (UK). The successful candidate will provide scientific expertise in assay development for drug discovery using 4D pharma's proprietary MicroRx® platform to identify candidate LPBs for different therapeutic areas. This is mainly focussed on defining suitable properties of LBPs in CNS diseases using appropriate in vitro, in vivo and ex vivo readouts by integrating cellular, molecular, immune and neurological endpoints to study the modulation of the gut-brain axis and support translational development of LBPs. Knowledge of gut-microbiota-brain communication is highly desirable.

Technical requirements for this position include first-hand experience with techniques in cell and tissue culture, animal handling and behaviour, microscopy imaging as well as molecular biology techniques (e.g. transcriptomics), as well as the proven ability to translate these skills into robust and reliable data. The post holder will be expected to personally execute laboratory activities, and to supervise and mentor junior team members in various lab-based activities. We are seeking an individual with a proven ability to develop and undertake high quality research. The post-holder will have the opportunity to engage in the wider research activities of the 4D Pharma Research team, write up results in the form of reports and publications, present research outcomes at meetings, and generate intellectual property.


Experience / Qualifications Required

  • MSc. or Ph.D. in Neuroscience or other relevant discipline, ideally with a minimum of 3 years’ experience working in an industrial environment in a similar role
  • Strong background and research training in neuroscience, cellular and molecular biology, immunology, and/or microbiology
  • Experience in designing and performing routine and complex laboratory procedures and assays (in vitro and ex vivo), including molecular, cellular and biochemical techniques in order to understand the in-depth molecular signatures of cellular components of the gut-brain axis in health and disease
  • Interest in exploring mechanisms underlying protein misfolding/spread leading to neurodegeneration in the enteric, peripheral, and central nervous systems to uncover new therapeutic targets
  • Experience in conducting in vivo experiments to study disease pathophysiology from the gut to the brain and validate new targets
  • Personal licence ownership or willingness to acquire licence desirable
  • Expertise in data analysis focusing on one or more neurological disorder (i.e., Parkinson’s disease, Alzheimer’s disease, Stroke, etc.)
  • Proficiency with primary rodent and iPSC human neuronal cell cultures and complex in vitro models is preferred Interest and focus on interdisciplinary work, strong communication and interpersonal skills
  • Excellent analytical, problem-solving, and organisational skills with attention to detail
  • Experience in supervising junior members of staff


Key Areas of Responsibility

  • Assay development and validation for the characterisation of LBPs
  • Analyse data and report results to the Team Leader and other senior members of staff
  • Perform laboratory techniques and protocols according to SOPs
  • Provide scientific expertise to the Discovery (Host) team Keep accurate and detailed records of data
  • Attend and contribute to research group meetings
  • Train junior members of the team


How to apply

Please send all applications to:

Lucy Christie

hr@4dpharmaplc.com

Telephone 01224 900 460

About the Company

4D pharma plc is a pharmaceutical company focussed on developing therapeutics from the human gut microbiome. Live biotherapeutic products (LBPs) derived from the gut microbiome represent a new class of drug that contain live organisms for the prevention, treatment or cure of disease. 4D pharma is a world leader in the LBP field and currently has a number of clinical stage programs in oncology, asthma, IBS and IBD, and a strong pipeline of additional pre-clinical programs in CNS disease, oncology, autoimmunity and inflammation.


Purpose of the Job

The successful candidate will support the activities of the Microbiology team at 4D Pharma Research Ltd in Aberdeen. This will primarily involve applying metabolomics approaches to understand the mode of action of LBP candidates and mining the 4D Pharma bacterial culture collection to identify and characterise microbial metabolites with the potential to mediate host-microbe interactions. This work will include the characterisation of the metabolic profiles of bacterial strains using targeted and untargeted metabolomic analysis tools.

A strong background in a wide range of microbiological techniques is therefore required for this position with a particular emphasis on mass spectrometry, HPLC and other techniques required for the quantification of bacterial metabolites. Previous experience in short-chain fatty acid quantification would be of advantage to this role.


Experience / Qualifications Required

  • MSc in Microbiology, Biochemistry, Biotechnology or a related discipline, with at least a year of academic or industry experience
  • Experience with HPLC and mass spectrometry techniques with experience in HPLC method development
  • Experience with detection, quantification, and purification of bacterial metabolites
  • Previous laboratory experience and ability to follow SOPs
  • Experience in a range of microbiological techniques
  • Experience working with anaerobic bacteria would be advantageous


Key Areas of Responsibility

  • Develop methods to quantify bacterial metabolites
  • Provide technical support to the Microbiology team
  • Keep accurate and detailed records of data
  • Report results to the team lead and research scientists within the team
  • Attend and contribute to research group meetings
  • General laboratory and equipment maintenance and stock control


How to apply

Please send all applications to:

Lucy Christie

hr@4dpharmaplc.com

Telephone 01224 900 460

About the Company

4D Pharma PLC is a pharmaceutical company focussed on developing therapeutics from the human gut microbiome. Live biotherapeutic products (LBPs) derived from the gut microbiome represent a new class of drugs that contain live organisms for the prevention, treatment, or cure of disease. 4D Pharma is a world leader in the LBP field and currently has a number of clinical stage programmes (in IBS, IBD, oncology and asthma) and a strong pipeline of additional pre-clinical programmes in autoimmunity, inflammation, and CNS diseases.


Purpose of the Job

The successful candidate will support the activities of the Microbiology Team at 4D Pharma Research Ltd in Aberdeen. This will primarily involve the culturing of bacterial cells for screening assays and performing phenotypic assays to identify and characterisatise bacterial strains. Previous relevant experience in microbiology and excellent aseptic technicial skills are essential to this role.

The post-holder will also be responsible for preparing reagents, maintaining laboratory stock levels and performing data entry and processing. The ability to record data with a high level of accuracy will be essential to this role. Training for specific assays and techniques will be provided and a degree of flexibility in regard to working hours will be required for this role.


Experience / Qualifications Required

  • BSc degree or Higher National Certificate (HND) in microbiology, biochemistry, biology or biomedical sciences
  • Competency in a variety of microbiological laboratory techniques
  • Experience in bacterial culturing techniques is essential to this role and a knowledge of handling requirements for strict anaerobes would be highly valuable
  • Strong aseptic technical skills.
  • Basic experience of molecular biology techniques would be advantageous
  • Ability to follow SOPs and an awareness of GLP practices
  • Excellent organisational skills and accurate record keeping, attention to detail


Key Areas of Responsibility

  • Provide technical support to the Microbiology Team
  • Perform microbiological laboratory techniques and protocols
  • Keep accurate and detailed records of data
  • Attend and contribute to research group meetings
  • Flexible working hours with early and late shifts


How to apply

Please send all applications to:

Lucy Christie

Email hr@4dpharmaplc.com

Telephone 01224 900 460

About the Company

4D Pharma PLC is a pharmaceutical company focussed on developing therapeutics from the human gut microbiome. Live biotherapeutic products (LBPs) derived from the gut microbiome represent a new class of drugs that contain live organisms for the prevention, treatment, or cure of disease. 4D Pharma is a world leader in the LBP field and currently has a number of clinical stage programmes (in IBS, IBD, oncology and asthma) and a strong pipeline of additional pre-clinical programmes in autoimmunity, inflammation, and CNS diseases.


Purpose of the Job

The successful candidate will support the activities of the Microbiology/Engineering team at 4D Pharma Research Ltd in Aberdeen. This will primarily involve performing cloning and bacterial transformations and applying functional genomics approaches understand the mode of action of candidate LBPs. Previous relevant experience in molecular microbiology is essential to this position as is the ability to record data with a high level of accuracy. Training for specific assays and techniques will be provided. The post-holder will also be responsible for preparing reagents and maintaining stock levels, along with sample database management.


Experience / Qualifications Required

  • BSc degree in genetics, molecular biology or microbiology with at least 1 year’s relevant experience in the research area
  • Experience in a range of molecular microbiology techniques including nucleic acid extractions, primer design, cloning, and bacterial mutagenesis approaches
  • Previous laboratory experience and ability to follow SOPs
  • Experience in a range of microbiological techniques and strong aseptic technical skills
  • Basic bioinformatics skills and experience working with anaerobic bacteria would be advantageous


Key Areas of Responsibility

  • Provide technical support to the Microbiology/Engineering team
  • Keep accurate and detailed records of data
  • Report results to the senior research scientist within the team
  • Attend and contribute to research group meetings
  • General laboratory maintenance and stock control


How to apply

Please send all applications to:

Lucy Christie

hr@4dpharmaplc.com

Telephone 01224 900 460

About the Company

4D Pharma PLC is a pharmaceutical company focussed on developing therapeutics from the human gut microbiome. Live biotherapeutic products (LBPs) derived from the gut microbiome represent a new class of drugs that contain live organisms for the prevention, treatment, or cure of disease. 4D Pharma is a world leader in the LBP field and currently has a number of clinical stage programmes (in IBS, IBD, oncology and asthma) and a strong pipeline of additional pre-clinical programmes in autoimmunity, inflammation, and CNS diseases.


Purpose of the Job

Applications are invited for the role of Senior Scientist in Microbiology to join the research team at 4D Pharma Research Ltd in Aberdeen (UK). The successful candidate will provide scientific expertise to the proprietary MicroRx platform, for the early discovery of new LBPs in novel therapeutic areas. This role will involve developing and implementing novel strategies for the isolation of bacterial strains from healthy human donor samples. Knowledge of the phylogenetic composition of the human gut microbiome is essential to this role. A strong background in bacterial community dynamics and an understanding of synthetic gut microbiome systems would also be highly advantageous.

The successful candidate will manage the 4D Pharma Faecal Bank, including the active recruitment of new donors and management of sample collection, processing, and storage. Previous experience in the curation of clinical sample biobanks would be advantageous. The post-holder will have the opportunity to engage in the wider research activities of the 4D Pharma Research team, write up results in the form of reports and publications, present research outcomes at meetings, and generate intellectual property.


Experience / Qualifications Required

  • A PhD with relevant post-doctoral or industry experience (>3 years) in microbiology or a related discipline
  • Extensive experience in culturomics and anaerobic microbiological techniques
  • Experience in the targeted and untargeted isolation of bacterial strains from biological samples
  • Experience in the identification and taxonomic classification of bacterial strains
  • Knowledge of the phylogenomic composition of the human gut microbiome
  • Knowledge of current gut microbiome research activities would be advantageous.
  • Highly motivated and innovative with the ability to work independently and integrate into a multidisciplinary team of microbiologists and molecular biologists


Key Areas of Responsibility

  • Development and implementation of strategies for the isolation of bacterial strains from healthy human donor samples
  • Management of the 4D Pharma Faecal Bank including the recruitment of new donors.
  • Provide scientific expertise in bacterial taxonomic classification and phylogenetic analyses
  • Work as part of the 4D Pharma Research Team to plan research activities within the framework of the agreed programmes


How to apply

Please send all applications to:

Lucy Christie

hr@4dpharmaplc.com

Telephone 01224 900 460

We always welcome applications from talented individuals even if a role is not advertised we would be keen to hear from you. Please send your CV to hr@4dpharmaplc.com

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